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LAB NEWS ARCHIVES
-Former postdoc Simon Chan was promoted to Full Professor at the Hong Kong University of Science and Technology!
-A new startup company from the Dedon Lab, Proteomax, was selected from among 600 entrants for the final three in the Temasek Foundation Liveability Challenge for S$1M. Proteomax uses technology from SMART and MIT to enhance biomanufacturing of food proteins. Though the team did not win the TLC, the exposure to investors and customers has dramatically propelled their fundraising efforts.
-Welcome Ochiba Attah to the Dedon Lab! Ochiba is working on a microbiome epigenetics computational genomics project for her Master’s Degree in Electrical Engineering and Computer Science.
-Welcome 30 Singaporean scientists and PIs from the SMART Antimicrobial Resistance IRG to MIT for AMR@MIT Week!
-Welcome postdoc Ruixi Chen! Ruixi completed his PhD in Food Science and Technology at Cornell University, studying microbial genomics and computational biology.
Pete Dedon receives the American Chemical Society Toxicology Division Founders Award and delivers the Loeppky Lecture Click for Pete's Loeppky Lecture
Dr. Junzhou Wu delivers a talk at the Fall 2020 ACS Meeting on Derivatization of Phosphorothioate DNA Modifications by Direct Chemical Conjugation Click for Junzhou's Talk
Pete Dedon interviewed on Singapore Tonight about phage epigenetics discoverieshttps://www.youtube.com/watch?v=HUQNbIEwkA8
Peter Dedon interviewed on The Takeaway (WNYC Studios) about the use of hydroxychloroquine for COVID-19: "Trump Continues to Promote Hydroxychloroquine as a Treatment for COVID-19 Despite Lack of Evidence" https://www.wnycstudios.org/podcasts/takeaway/segments/trump-hydroxychloroquine-covid19
Discovery of a new epigenetic defense mechanism used by bacteriophage (Nature Microbiology, https://doi.org/10.1038/s41564-020-0700-6)
MIT News: "SMART researchers uncover new anti-phage defense mechanisms"http://news.mit.edu/2020/smart-researchers-uncover-new-anti-phage-defence-mechanisms-bacteria-0513/
Science Daily: "SMART researchers uncover new anti-phage defence mechanisms in bacteria" https://www.sciencedaily.com/releases/2020/05/200506133608.htm
Phys.org: "Researchers uncover new anti-phage defense mechanisms in bacteria"
https://phys.org/news/2020-05-uncover-anti-phage-defense-mechanisms-bacteria.html
NIEHS Environmental Factor: Dedon and Alm awarded NIH Transformative Award for Epigenetics of the Human Gut Microbiome
https://factor.niehs.nih.gov/2019/11/awards-recognition/gut-microbiome/index.htm
MIT News: Eric Alm and Peter Dedon receive NIH Transformative Research Award
http://news.mit.edu/2019/mit-alm-dedon-receive-nih-transformative-research-award-1024
tRNA-mediated codon-biased translation in mycobacterial hypoxic persistence
Cracking the code for dormant bacteria: Newly discovered genetic code controls bacterial survival during infections, by Anne Trafton.
http://news.mit.edu/2016/cracking-code-dormant-bacteria-infections-1111
http://phys.org/news/2016-11-newly-genetic-code-bacterial-survival.html
Discovery by scientists here may help fight against TB, by Nadia Chevroulet
http://www.straitstimes.com/singapore/discovery-by-scientists-here-may-help-fight-against-tb
A new way to discover DNA modifications
ScienceDaily, 29 February 2016.
www.sciencedaily.com/releases/2016/02/160229182542.htm
Cellular stress reprograms RNA modifications and exploits biased codon distributions in the genome to selectively translate critical proteins
“Genetic 911: Cells’ emergency systems revealed - Study examines how cells exploit gene sequences to cope with toxic stress” by Anne Trafton, MIT News Office
http://web.mit.edu/newsoffice/2012/cell-emergency-response-0703.html
“Research team uncovers a new cellular stress response mechanism” by Melissa Kerr, NIEHS Environmental Factor, August 2012
http://www.niehs.nih.gov/news/newsletter/2012/8/science-stress/index.htm
Infection-induced inflammation as a cause of cancer: Study offers comprehensive look at chemical and genetic changes that occur as inflammation progresses to cancer
How infection can lead to cancer: New MIT study offers comprehensive look at chemical and genetic changes that occur as inflammation progresses to cancer, by Anne Trafton, MIT News Office
http://web.mit.edu/newsoffice/2012/cancer-inflammation-h-pylori-0611.html
“How do infections lead to cancer?” by Charlie Osborne, SmartPlanet
http://www.smartplanet.com/blog/smart-takes/how-do-infections-lead-to-cancer/27140
“From Infection To Inflammation To Cancer: Scientists Offer New Clues” by Catharine Paddock PhD, Medical News Today
http://www.medicalnewstoday.com/articles/246523.php
The genetic toxicology of defects and polymorphisms in purine metabolism
"Metabolic errors can spell doom for DNA" by Anne Trafton January 31, 2012.
http://web.mit.edu/newsoffice/2012/dna-metabolic-errors-0131.html
MIT Home Page Spotlight Archive - "Metabolic errors can spell doom for DNA" Tuesday January 31, 2012.
http://web.mit.edu/site/date/2012/1/
"MIT: Defective enzymes may spell higher cancer risk" by Lori Valigra January 30, 2012.
http://www.masshightech.com/stories/2012/01/30/daily56-MIT-Defective-enzymes-may-spell-higher-cancer-risk.html
Discovery of paradoxical DNA damage caused by a chemical mediator of inflammation
“DNA damage study probes inflammation, disease link” by Anne Trafton July 26, 2006.
http://web.mit.edu/newsoffice/2006/dna-damage.html
“Saúde Integral: DNA damage study probes inflammation, disease link”.
http://saudeintegralecia.blogspot.com/2007/07/dna-damage-study-probes-inflammation.html
“PhysOrg: DNA damage study probes inflammation, disease link”.
http://www.physorg.com/news73058892.html
News story on ACS Symposium, “Zebrafish in Drug Discovery”
“ZEBRAFISH IN DRUG DISCOVERY: ACS MEETING NEWS - Small fish can impact drug and target screening in a big way” by Carmen Drahl, C&EN WASHINGTON, Chem. Eng. News, 2007, 85 (39), pp 103–105
“The Sceptical Chymist - ACS: So long, and thanks for all the fish”, by Catherine Goodman, Associate Editor, Nature Chemical Biology.
http://blogs.nature.com/thescepticalchymist/2007/08/acs_so_long_and_thanks_for_all.html
Discovery of phosphorothioates in bacteria
“MIT team discovers bacterial surprise. A DNA shift never before seen in nature.” By Anne Trafton
http://web.mit.edu/newsoffice/2007/dna-modification-1203.html
"SULFUR SURPRISE: This dinucleotide, which occurs naturally in bacterial genomic DNA, possesses a sulfur atom in place of one of the nonbridging oxygen atoms on its phosphate group". Reported by Chemical & Engineering News Oct. 22, 2007, 14.
“MIT team discovers bacterial surprise”.
http://www.theallineed.com/biology/08012211.htm
“Bacteria Employ Type Of DNA Modification Never Before Seen In Nature”.
http://www.sciencedaily.com/releases/2007/12/071203142430.htm
“Researchers discover DNA shift never before seen in nature: A team of MIT researchers and others has discovered that bacteria employ a type of DNA modification never before seen in nature”.
http://www.physorg.com/news115914209.html
“Equipo del MIT descubre sorpresa bacteriana: MIT team discovers bacterial surprise A DNA shift never before seen in nature”.
http://www.biopps.com/article.php/bacterial-surprise/print
Popular Science interview on radiation and human health following the Fukushima disaster
“FYI: How Does Nuclear Radiation Do Its Damage? Or, why everyone is stocking up on iodine tablets” by Molika Ashford. http://www.popsci.com/science/article/2011-03/fyi-how-does-nuclear-radiation-do-its-damage
Confirming the link between inflammation and cancer
“MIT confirms link between inflammation, cancer”.
http://web.mit.edu/newsoffice/2008/gastric-cancer-0602.html
“Inflammation: Link Between Chronic Inflammation And Cancer Confirmed”.
http://www.vaccinetruth.org/inflammation.htm
“Science Daily: Link Between Inflammation, Cancer Confirmed”.
http://www.sciencedaily.com/releases/2008/06/080602214138.htm
“Medical News Today: Link Between Chronic Inflammation And Cancer Confirmed”.
http://www.medicalnewstoday.com/articles/110340.php
“Study confirms link between inflammation, cancer”.
http://www.physorg.com/news131646111.html
Discovery of tRNA modification reprogramming in cell survival response
Nature Methods story on tRNA modifcation programming: “Stress survival: Better living through biochemistry” by Michael Eisenstein.
http://www.signaling-gateway.org/update/updates/201102/nmeth0211-108b.html
“The code for survival. Cells fight stress by reprogramming a system of RNA modifications, researchers find” by Anne Trafton.
http://web.mit.edu/newsoffice/2010/cell-stress-1217.html (MIT homepage spotlight and story)
http://web.mit.edu/press/2010/cell-stress-1217.html (press release)
“The code for survival”.
http://www.tobimichigan.com/?p=1009
“A View of Cellular Emergency Repair Mechanism”.
http://news.softpedia.com/news/A-View-of-Cellular-Emergency-Repair-Mechanisms-173337.shtml
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