Lab News    |   Photos of Dedon Lab Events

tRNA-mediated codon-biased translation in mycobacterial hypoxic persistence
Cracking the code for dormant bacteria: Newly discovered genetic code controls bacterial survival during infections, by Anne Trafton.
http://news.mit.edu/2016/cracking-code-dormant-bacteria-infections-1111
http://phys.org/news/2016-11-newly-genetic-code-bacterial-survival.html

 

Discovery by scientists here may help fight against TB, by Nadia Chevroulet.
http://www.straitstimes.com/singapore/discovery-by-scientists-here-may-help-fight-against-tb

 

A new way to discover DNA modifications
ScienceDaily, 29 February 2016.
www.sciencedaily.com/releases/2016/02/160229182542.htm

 

Cellular stress reprograms RNA modifications and exploits biased codon distributions in the genome to selectively translate critical proteins

“Genetic 911: Cells’ emergency systems revealed - Study examines how cells exploit gene sequences to cope with toxic stress” by Anne Trafton, MIT News Office
http://web.mit.edu/newsoffice/2012/cell-emergency-response-0703.html

“Research team uncovers a new cellular stress response mechanism” by Melissa Kerr, NIEHS Environmental Factor, August 2012
http://www.niehs.nih.gov/news/newsletter/2012/8/science-stress/index.htm

 

Infection-induced inflammation as a cause of cancer: Study offers comprehensive look at chemical and genetic changes that occur as inflammation progresses to cancer

How infection can lead to cancer: New MIT study offers comprehensive look at chemical and genetic changes that occur as inflammation progresses to cancer, by Anne Trafton, MIT News Office
http://web.mit.edu/newsoffice/2012/cancer-inflammation-h-pylori-0611.html

“How do infections lead to cancer?” by Charlie Osborne, SmartPlanet
http://www.smartplanet.com/blog/smart-takes/how-do-infections-lead-to-cancer/27140

“From Infection To Inflammation To Cancer: Scientists Offer New Clues” by Catharine Paddock PhD, Medical News Today
http://www.medicalnewstoday.com/articles/246523.php

 

The genetic toxicology of defects and polymorphisms in purine metabolism

"Metabolic errors can spell doom for DNA" by Anne Trafton January 31, 2012.
http://web.mit.edu/newsoffice/2012/dna-metabolic-errors-0131.html

MIT Home Page Spotlight Archive - "Metabolic errors can spell doom for DNA" Tuesday January 31, 2012.
http://web.mit.edu/site/date/2012/1/

"MIT: Defective enzymes may spell higher cancer risk" by Lori Valigra January 30, 2012.
http://www.masshightech.com/stories/2012/01/30/daily56-MIT-Defective-enzymes-may-spell-higher-cancer-risk.html

 

Discovery of paradoxical DNA damage caused by a chemical mediator of inflammation

“DNA damage study probes inflammation, disease link” by Anne Trafton July 26, 2006.
http://web.mit.edu/newsoffice/2006/dna-damage.html

“Saúde Integral: DNA damage study probes inflammation, disease link”.
http://saudeintegralecia.blogspot.com/2007/07/dna-damage-study-probes-inflammation.html

“PhysOrg: DNA damage study probes inflammation, disease link”.
http://www.physorg.com/news73058892.html

 

News story on ACS Symposium, “Zebrafish in Drug Discovery”

“ZEBRAFISH IN DRUG DISCOVERY: ACS MEETING NEWS - Small fish can impact drug and target screening in a big way” by Carmen Drahl, C&EN WASHINGTON, Chem. Eng. News, 2007, 85 (39), pp 103–105

“The Sceptical Chymist - ACS: So long, and thanks for all the fish”, by Catherine Goodman, Associate Editor, Nature Chemical Biology.
http://blogs.nature.com/thescepticalchymist/2007/08/acs_so_long_and_thanks_for_all.html

 

Discovery of phosphorothioates in bacteria

“MIT team discovers bacterial surprise. A DNA shift never before seen in nature.” By Anne Trafton
http://web.mit.edu/newsoffice/2007/dna-modification-1203.html

"SULFUR SURPRISE: This dinucleotide, which occurs naturally in bacterial genomic DNA, possesses a sulfur atom in place of one of the nonbridging oxygen atoms on its phosphate group". Reported by Chemical & Engineering News Oct. 22, 2007, 14.

“MIT team discovers bacterial surprise”.
http://www.theallineed.com/biology/08012211.htm

“Bacteria Employ Type Of DNA Modification Never Before Seen In Nature”.
http://www.sciencedaily.com/releases/2007/12/071203142430.htm

“Researchers discover DNA shift never before seen in nature: A team of MIT researchers and others has discovered that bacteria employ a type of DNA modification never before seen in nature”.
http://www.physorg.com/news115914209.html

“Equipo del MIT descubre sorpresa bacteriana: MIT team discovers bacterial surprise A DNA shift never before seen in nature”.
http://www.biopps.com/article.php/bacterial-surprise/print

 

Popular Science interview on radiation and human health following the Fukushima disaster

“FYI: How Does Nuclear Radiation Do Its Damage? Or, why everyone is stocking up on iodine tablets” by Molika Ashford. http://www.popsci.com/science/article/2011-03/fyi-how-does-nuclear-radiation-do-its-damage

 

Confirming the link between inflammation and cancer

“MIT confirms link between inflammation, cancer”.
http://web.mit.edu/newsoffice/2008/gastric-cancer-0602.html

“Inflammation: Link Between Chronic Inflammation And Cancer Confirmed”.
http://www.vaccinetruth.org/inflammation.htm

“Science Daily: Link Between Inflammation, Cancer Confirmed”.
http://www.sciencedaily.com/releases/2008/06/080602214138.htm

“Medical News Today: Link Between Chronic Inflammation And Cancer Confirmed”.
http://www.medicalnewstoday.com/articles/110340.php

“Study confirms link between inflammation, cancer”.
http://www.physorg.com/news131646111.html

 

Discovery of tRNA modification reprogramming in cell survival response

Nature Methods story on tRNA modifcation programming: “Stress survival: Better living through biochemistry” by Michael Eisenstein.
http://www.signaling-gateway.org/update/updates/201102/nmeth0211-108b.html

“The code for survival. Cells fight stress by reprogramming a system of RNA modifications, researchers find” by Anne Trafton.
http://web.mit.edu/newsoffice/2010/cell-stress-1217.html (MIT homepage spotlight and story)
http://web.mit.edu/press/2010/cell-stress-1217.html (press release)

“The code for survival”.
http://www.tobimichigan.com/?p=1009

“A View of Cellular Emergency Repair Mechanism”.
http://news.softpedia.com/news/A-View-of-Cellular-Emergency-Repair-Mechanisms-173337.shtml