The Dedon research group seeks to understand the chemical etiology of human disease, with the long-term goals of developing diagnostic tools and therapies. Using both data- and hypothesis-driven approaches, the research team develops ultra-sensitive bioanalytical tools to characterize and quantify normal and damaged biomolecules in cells and tissues and to interrogate biochemical networks and systems. The current research program has a broad theme of nucleic acid chemistry and biology with a focus on microbial pathogens, inflammation and cancer in four major projects:
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The genetic toxicology of defects and polymorphisms in purine metabolism. >>
Phosphorothioate modification of DNA in bacteria genomes is quantized as part of a novel restriction-modification system. >>
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